The theranostic efficiency of tumor-specific, pH-responsive, peptide-modified, liposome-containing paclitaxel and superparamagnetic iron oxide nanoparticles

نویسندگان

  • Xiu-Chai Zheng
  • Wei Ren
  • Shuang Zhang
  • Ting Zhong
  • Xiao-Chuan Duan
  • Yi-Fan Yin
  • Mei-Qi Xu
  • Yan-Li Hao
  • Zhan-Tao Li
  • Hui Li
  • Man Liu
  • Zhuo-Yue Li
  • Xuan Zhang
چکیده

Background In the present study, the tumor-specific, pH-responsive peptide H7K(R2)2-modified, theranostic liposome-containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7K(R2)2, was prepared by using H7K(R2)2 as the targeting ligand, SPIO NPs as the magnetic resonance imaging (MRI) agent, PTX as antitumor drug. Methods The PTX/SPIO-SSL-H7K(R2)2 was prepared by a thin film hydration method. The characteristics of PTX/SPIO-SSL-H7K(R2)2 were evaluated. The targeting effect, MRI, and antitumor activity of PTX/SPIO-SSL-H7K(R2)2 were investigated detail in vitro and in vivo in human breast carcinoma MDA-MB-231 cell models. Results Our results of in vitro flow cytometry, in vivo imaging, and in vivo MR imaging confirmed the pH-responsive characteristic of H7K(R2)2 in MDA-MB-231 cell line in vitro and in vivo. The results of in vivo MRI and in vivo antitumor activity confirmed the theranostic effect of PTX/SPIO-SSL-H7K(R2)2 in MDA-MB-231 tumor-bearing model. Conclusion Considering all our in vitro and in vivo results, we conclude that we developed targeting modified theranostic liposome which could achieve both role of antitumor and MRI.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging

Theranostic nanoparticles based on superparamagnetic iron oxide (SPIO) have a great promise for tumor diagnosis and gene therapy. However, the availability of theranostic nanoparticles with efficient gene transfection and minimal toxicity remains a big challenge. In this study, we construct an intelligent SPIO-based nanoparticle comprising a SPIO inner core and a disulfide-containing polyethyle...

متن کامل

Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy

Superparamagnetic iron oxide nanoparticles (SPION) are an important and versatile nano- platform with broad biological applications. Despite extensive studies, the biological and pharmacological activities of SPION have not been exploited in therapeutic applications. Recently, β-lapachone (β-lap), a novel anticancer drug, has shown considerable cancer specificity by selectively increasing react...

متن کامل

Selective Removal of Lead (II) Ion from Wastewater Using Superparamagnetic Monodispersed Iron Oxide (Fe3O4) Nanoparticles as a Effective Adsorbent

This study investigated the applicability of polyethylene glycol (PEG-4000) coated Fe3O4 magnetic nanoparticles for the selective removal of toxic pb (II) ion from wastewater. The Fe3O4 magnetic nanoparticles of 24 nm were synthesized using a coprecipitation method and characterized by Scanning electron microscopy (SEM), vibratingsample magnetometer (VSM), and X-ray diffraction (XRD). SEM image...

متن کامل

Core-shell magnetic pH-responsive vehicle for delivery of poorly water-soluble rosuvastatin

Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic aci...

متن کامل

Potential positive MRI contrast agent based on PVP-grafted superparamagnetic iron oxide nanoparticles with various repetition times

Objective(s): The present study aimed to evaluate the capability of synthesized and modified superparamagnetic iron oxide nanoparticles (SPIONs) as the positive contrast agent in magnetic resonance imaging (MRI) by investigating the effect of repetition time (TR) on the MRI signal intensity. Materials and Methods: SPIONs were synthesized using the co-precipitation method, and their surfac...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2018